The lawsuits involving Nexium and Prilosec state the manufacturers failed to warn patients and physicians of the increased risks of kidney damage, renal failure and ischemic stroke.
Plaintiffs lawyers argue that if the manufacturers had properly warned of the risks, patients would have been prescribed a different medication for their acid-related stomach issues, and certainly would have had their health monitored on a more frequent basis for potential signs of kidney disease and future strokes.
Are Nexium and Prilosec the Same Drug
Esomeprazole (Nexium) is a “mirror drug”, meaning that is extremely similar to omeprazole (Prilosec), just like the left hand is the “mirror image” of the right hand. Technically they could be safely considered as the same drug. However, shortly after Prilosec’s patent ended, AstraZeneca obtained FDA’s approval to market Nexium as a new drug just before the market was flooded with generic medications. Mamy speculated that the pharmaceutical giant manufactured the new medication in order to maintain their revenues, since in the early 2000s Prilosec was the top-selling prescription medicine in the U.S., with yearly sales of $4.1 billion.
Esomeprazole and the other PPIs are among the most overprescribed medications in the entire world, and they’re also grossly overpriced, especially in the United States. According to the American Society of Health-System Pharmacists, generic omeprazole is sold at about $1 per single dose, while esomeprazole’s price is usually 7 to 15 times higher. Dr. Marcia Angell, the former editor-in-chief of the New England Journal of Medicine, accused AstraZeneca of distorting the results of the studies that allegedly demonstrated esomeprazole’s superiority over omeprazole to artificially overcharge the American consumers.
Why is Nexium and Prilosec Utilized
Nexium & Prilosec are drugs called proton pump inhibitors. They are used to treat gastroesophageal reflux disease, by reducing the amount of acid in a person’s stomach. They also may be prescribed to heal acid-related damage to the lining of the esophagus; to reduce stomach ulcers; and to treat stomach infections.
Approximately 15 million Americans use proton pump inhibitors. However, as many as 25% of long-term users could stop taking the medication without suffering increased heartburn or acid reflux, according to researchers at Johns Hopkins University.
Nexium and Prilosec Injuries & Side Effects
The most serious potential side effects and risks caused through the use of Nexium & Prilosec are strokes, bone fractures, kidney disease, renal failure and heart damage.
People who take multiple daily doses for a long period of time (a year or longer), especially those 50 years of age or older, have an increased risk of fractures of the hip, wrist, and spine. Additionally, people who use the drugs appear to have a 20-50% higher risk of chronic kidney disease compared with nonusers, and a 20-30% increased risk for stroke.
|Less Serious Side Effects|
|Chronic inflammation of the stomach lining|
|Low magnesium levels|
It’s very important to tell your doctor if you experience any of the following problems: (i) kidney disease; (ii) osteoporosis; (iii) low bone mineral density (osteopenia); (iv) numbness in the face, arm or leg; (v) confusion or trouble speaking; (vi) loss of vision; (vii) dizziness; (viii) difficulty walking; (ix) severe headache; or (x) low levels of magnesium in your blood.
Gastric tumors, bone fractures and anemia
Nexium and Prilosec do more than just reduce gastric acid, they also reduce the secretion of several other substances produced by stomach cells. Those substances are required for proper absorption of many important nutrients such as Vitamin C, Vitamin B12, calcium and magnesium.
Malabsorption is especially dangerous in frail and dangerous subjects, as it may lead to many nutritional deficiencies. Long-term use of PPIs has been associated with iron deficiency anemia, hypomagnesemia and pernicious anemia. The use of PPIs for extend periods may also reduce bone strength, increasing the risk of hip, spine and wrist fractures.
PPIs also indirectly increase the production of other substances such as gastrin in vast excess. Hypergastrinemia has been associated with an increased risk of gastric tumors as well as with other cancer malignancies in patients affected by GERD.
Cardiovascular diseases and heart attacks
According to a large clinical study called PLOS ONE, the use of Nexium and other PPIs has been associated with an estimated increase in heart attack risk of 16-21%. These drugs can reduce the production of a substance that protects blood vessels. The internal lining of the vessels is then damaged, increasing the formation of dangerous blood clots and other cardiovascular diseases.
Chronic kidney disease
PPIs are linked with a 20 to 50 percent higher risk of chronic kidney disease (CKD), as demonstrated by a large study published in the JAMA Internal Medicine journal. The risk is higher in patients who took higher doses of these medications. CKD causes a gradual loss of kidney function that may also lead to renal failure.
An ischemic stroke occurs when the flow of blood and oxygen to the brain is reduced, causing the brain cells and tissue to die. PPIs are linked to a 20-30% increased risk of strokes depending upon the dosage the person is taking per day.
Pneumonia, diarrhea and systemic infections
A proper gastric acid secretion is critical to our health. PPIs reduce acid secretion by up to 99% which is much more than is usually required by most patients, especially if these drugs are taken for extended periods of time.
Hydrochloric acid is, in fact, a barrier to sterilize the food we eat, killing most microbes such as bacteria and viruses. Without stomach acid, patients are at a greater risk of serious infections including Clostridium difficile enteritis, diarrhea and pneumonia.
Risk of Dementia
A study published in the journal JAMA Neurology showed that regular use of these medications was linked with a 50 percent increased risk of dementia in elderly patients. Researchers analyzed data from about 74,000 patients over a period of 7 years, and explained that in those countries where PPIs are available as OTC medications (such as the United States), the risk may be even higher.
Nexium & Prilosec Lawsuit News
A popular group of antacids known as proton pump inhibitors, or PPIs, used to reduce stomach acid and treat heartburn may increase the risk of ischemic stroke, according to preliminary research presented at the American Heart Association's Scientific Sessions 2016. To read more, click EurekAlertNexium and Prilosec Linked to Kidney Damage, Heart Damage and Bone Fractures:
News of the connection between proton pump inhibitors (PPIs) such as Prilosec and Nexium has been out for several months, having been reported on Ring of Fire and elsewhere. That’s grim enough, but the latest news is even more alarming. It turns out that when it comes to PPIs, kidney disease is just the tip of the iceberg. These drugs do far more damage in more ways than previously thought. To read more, click Drug Safety NewsCommonly used heartburn drugs may lead to kidney damage: study:
Long-term use of a common type of medication used to treat heartburn, acid reflux, and ulcers may lead to an increased risk of kidney disease and kidney failure, new research shows. The study, published in the Journal of the American Society of Nephrology, adds to prior research that suggests proton-pump inhibitors (PPIs), a group of drugs which reduces gastric acid production, can lead to serious kidney damage. To read more, click CBS News
An estimated 15 million Americans are currently taking drugs like Nexium which work to control heartburn, indigestion, and acid reflux. Unfortunately, those who turn to Nexium and other Proton-pump inhibitors will need to proceed much more cautiously as studies have confirmed that taking these drugs increase the chance of kidney problems – and even kidney failure – by as much as fifty percent. To read more, click The Ring of FireCommon heartburn drugs linked with kidney disease:
People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers, said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore. . . . Use of the prescription heartburn drugs already has been linked to short-term kidney problems such as acute kidney injury and an inflammatory kidney disease called acute interstitial nephritis, Grams said. Newer studies now show a link between the drugs and chronic kidney disease, in which the kidneys lose their ability to filter blood effectively. Over time, chronic kidney disease can lead to kidney failure, forcing someone to undergo regular dialysis and possibly a kidney transplant, according to the U.S. National Institutes of Health. To read more, click CBS NewsHeartburn Drugs Tied to Higher Kidney Disease Risk:
A common type of heartburn medication called proton pump inhibitors (PPIs) seem to be linked with increased risk of chronic kidney disease, two new studies suggest. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. . . . They found that PPI users were up to 50 percent more likely to develop chronic kidney disease than non-PPI users, even after adjusting for differences between the two groups. To read more, click WebMDPopular Acid Reflux Drugs Are Linked To Kidney Disease Risk:
People who take certain popular medicines for heartburn, indigestion and acid reflux may want to proceed more cautiously, researchers reported Monday. The drugs, known as proton-pump inhibitors (PPIs), appear to significantly elevate the chances of developing chronic kidney disease, according to a study involving more than 250,000 people. An estimated 15 million Americans use PPIs, which are sold by prescription and over-the-counter under a variety of brand names, including Nexium, Prilosec and Prevacid. To read more, click NPRPopular heartburn medication linked to chronic kidney disease:
Widely popular heartburn medications that block the secretion of acid into the stomach are associated with higher rates of chronic kidney disease, according to a new study by Johns Hopkins University researchers released Monday. The research raises more questions about commonly used drugs such as Nexium, Prilosec and Prevacid, which had long been considered effective with few side effects. In June, an unusual data-mining project by Stanford University researchers revealed evidence linking the medications to a greater risk of heart attacks. Previous analyses have linked the medications to bone fractures, gut infections and other health problems. To read more, click Washington PostAmerican Heart Association: Proton Pump Inhibitors Increase Risk of Stroke:
The use of proton pump inhibitors (PPIs) such as Nexium and Prilosec for the treatment of heartburn has been linked to numerous side effects, leading to such conditions as kidney disease, osteoporosis, arterial injuries and buildup of serous fluid in the abdomen (a condition known as ascetes). Now, new research presented at the recent American Heart Association conference indicates that use of these medications result in a 20-90% greater risk of suffering an ischemic stroke. To read more, click Nexium's Link to StrokesDementia Linked to Nexium:
The study, carried out in Germany and published in the April 2016 issue of JAMA Neurology involved nearly 74,000 patients over the age of 75 (the average age being 83), examining data collected from a major German medical insurer over the course of seven years. The results indicated that elderly patients who regularly took proton pump inhibitors were at “a significantly increased risk of incident dementia” compared to those who did not take these drugs. To read more, click Nexium Might Speed Up DementiaPrilosec and Nexium: More Than Just Kidney Disease:
It turns out that when it comes to PPIs, kidney disease is just the tip of the iceberg. These drugs do far more damage in more ways than previously thought. At the top of the list: arterial damage. To read more, click Nexium Associated with Heart Damage
Nexium-Prilosec Lawsuit Videos
FDA and Scientific Studies Regarding Nexium & Prilosec
Proton Pump Inhibitor Use and the Risk of Chronic Kidney DiseaseProton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI use and chronic kidney disease (CKD). . . . Proton pump inhibitor use is associated with a higher risk of incident CKD. To read more, click Journal of American Medical Association
PPIs and kidney disease: from AIN to CKDProton pump inhibitors (PPIs) are commonly prescribed and available over-the-counter, and are taken by millions of patients around the world, often for many months to years. While PPIs have an excellent overall safety profile, concerns have been raised about adverse renal events, specifically their association with acute interstitial nephritis (AIN). While only a small proportion of patients develop AIN from PPIs, these drugs are now a common cause of drug-induced AIN in the developed world due to their widespread and prolonged use. To read more, click Journal of the American Society of Nephrology
Nexium and Prilosec Recall Information
As of this time, there has not been a recall of Nexium or Prilosec related to kidney damage. However, the investigation into these drugs, from a legal standpoint, are still at the early stages. It often takes many years; tens of thousands of hours of attorney time; and the expense of many millions of dollars before all the facts come out that will lead to a recall.
Nexium and Prilosec Settlement Information
As of this time, there have been no large group settlements involving Nexium or Prilosec and the potential link to kidney injuries or strokes. Litigation likes this takes many years to resolve, with teams of lawyers spending millions of dollars trying to determine exactly what occurred, and how it could have been prevented. Generally, large groups of settlements do not occur until such time as a few cases are tried before a jury, and the manufacturer is able to more thoroughly understand its financial risk.